Wieslawa Salwa-Zurawska(1), Elzbieta Bortkiewicz(2), Aldona Wozniak(1), Elzbieta Kaczmarek(3), Janusz Maciejewski(2)

Clinical and Morphological (Including Morphometric) Aspects of Minimal Change Disease and Mesangial Glomerulonephritis with Unfavourable Course in Children *

1)Chair and Department of Clinical Pathomorphology,
2)Department of Pediatric Diseases,
3)Department of Medical Statistics and Informatics, K. Marcinkowski School of Medicine, Poznan

Abstract

Clinical and morphological analysis was made to assess 9 cases of minimal change disease (MCD) and 30 cases of mesangial glomerulonephritis (GNMES) recognized by light microscopy with unfavourable course. Case selection was based exclusively on the clinical course suggesting a possibility of early sclerosis (long-term steroid resistance, frequent recurrences, rare short-lasting remissions, hypertension, renal failure). It was found that the unfavourable clinical course was clearly more frequently associated with electron microscopic than light microscopic changes. Marked increase of the matrix was observed also in those glomeruli in which light microscopy did not reveal any changes or only the signs of immaturity. It was also noticed that in those cases in which the assessment of mesangial matrix increase (which means the onset of sclerosis) is not certain, it is useful to make a morphometric analysis of electron microscopic material.

Address for correspondence and reprint requests to:
Prof. W. Salwa- Zurawska M. D.,
Chair and Department of Clinical Pathomorphology,
Przybyszewskiego 49, 60-355 Poznan.

*The study was supported by grant 4 PO5E 060 09 of the State Committee on Research.