Anna M. Kordowiak(1), Agnieszka Nikiforuk(1), Ryszard Grybos(2), Wojciech Dabros(3)

Biochemical and Morphological Study on Liver Golgi Complex in Streptozotocin-Diabetic and Control Rats Treated with bis(kojato)oxovanadium(IV) [VO(ka)2]x2H2O.
Part I. One Week Treatment with Vanadium Compound

1)Institute of Molecular Biology,
2)Department of Inorganic Chemistry,
3)Department of Clinical and Experimental Pathomorphology, Jagiellonian University, Kraków

Abstract

In comparison with untreated control, reduced body and liver weights were found in two groups of rats (such as control and STZ diabetic) treated orally with bis(kojato)oxovanadium(IV) solution. Free blood sugar in STZ-diabetic rats was lower by about 38%, but did not achieve euglycemic values. Yields of Golgi-rich fraction were lower than those in untreated controls, similar to the activity of galactosyl transferase (GalT) in both vanadium treated groups (control and diabetic). Under electron microscope in the control kojane-treated group, subcellular changes were observed. The morphology of Golgi apparatus was typical, resembled that in untreated animals. In diabetic animals treated with kojane subcellular changes were less severe. Golgi apparatus was usually semicircular or arched in shape similar to that observed previously in diabetic untreated rats.

Address for correspondence and reprint requests to:
W. Dabros Ph. D.,
Department of Pathomorphology, CMUJ,
Grzegorzecka 16, 31-531 Krakow.
mpdabros@cyf-kr.edu.pl